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Wissenschaftliche Publikationen


Aktuelles:

Jan Löhler, Orlando Guntinas-Lichius: TOTO Studie: Teilnehmer gesucht. Tonsillektomie oder Tonsillotomie - jetzt wollen wir es endlich wissen! 

(HNO Nachrichten 2020, 50(6))


Leitlinie Tonsillitis

Deutsches Register Klinischer Studien (DRKS)


Referenzen:

AWMF Leitlinie: Therapie entzündlicher Erkrankungen der Gaumenmandeln - Tonsillitis (2016). Nr. 017/024 

Altmann U, Worrack S, Kaczmarek MC, Mühleck J, Volk GF, Guntinas-Lichius O, Strauß BM. Akzeptanz emotionssensitiver Trainingssysteme von Patienten mit Fazialisparese und deren Angehöriger. Laryngorhinootologie. 2017 Jun; 96(6):380-387. German. doi: 10.1055/s-0043-100764. Epub 2017 Apr 26. PMID: 28445907. 

Bird JH, et al. (2014) Controversies in the management of acute tonsillitis: an evidence-based review. Clin Otolaryngol 39:368-374.  

Broemer L, Esser P, Koranyi S, Friedrich M, Leuteritz K, Wiegand S, Dietz A, Boehm A, Pabst F, Strauß BM, Guntinas-Lichius O, Mehnert A. Eine Gruppenintervention zur Förderung der Arbeitsfähigkeit für Patienten mit Kopf- Hals-Tumoren [A group intervention to promote work ability in patients with head and neck cancer]. Laryngorhinootologie. 2019 Mar; 98(3):175-182. German. doi: 10.1055/a-0829-6885. Epub 2019 Jan 24. PMID: 30677780. 

Burton MJ, et al. (2014) Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev 19; (11):CD001802# 

Dietz A, Wichmann G, Kuhnt T, Pfreundner L, Hagen R, Scheich M, Kölbl O, Hautmann MG, Strutz J, Schreiber F, Bockmühl U, Schilling V, Feyer P, de Wit M, Maschmeyer G, Jungehülsing M, Schroeder U, Wollenberg B, Sittel C, Münter M, Lenarz T, Klussmann JP, Guntinas-Lichius O, Rudack C, Eich HT, Foerg T, Preyer S, Westhofen M, Welkoborsky HJ, Esser D, Thurnher D, Remmert S, Sudhoff H, Görner M, Bünzel J, Budach V, Held S, Knödler M, Lordick F, Wiegand S, Vogel K, Boehm A, Flentje M, Keilholz U. Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy-final results of the larynx organ preservation trial DeLOS-II. Ann Oncol. 2018 Oct 1; 29(10):2105-2114. doi: 10.1093/annonc/mdy332. PMID: 30412221. 

Eckel HE, Schröder U, Jungehülsing M, Guntinas-Lichius O, Markitz M, Raunik W. Indikationen zur chirurgischen Therapie von Larynx- und Hypopharynxkarzinomen [Surgical treatment options in laryngeal and hypopharyngeal cancer]. Wien Med Wochenschr. 2008;158(9-10):255-63. German. doi: 10.1007/s10354-008-0530-2. PMID: 18560951. 

Georgalas CC, et al. Tonsillitis. BMJ Clin Evid 22; 2014. pii: 0503 

Geißler K, Markwart R, Requardt RP, Weigel C, Schubert K, Scherag A, Rubio I, Guntinas-Lichius O. Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis. PLoS One. 2017 Sep 6; 12(9):e0183214. doi: 10.1371/journal.pone.0183214. PMID: 28877231; PMCID: PMC5587326. 

Geißler K, Ducke M, Volk GF, Meißner W, Guntinas-Lichius O. Pain on the first postoperative day after tonsillectomy in adults: A comparison of metamizole versus etoricoxib as baseline analgesic. PLoS One. 2019 Aug 14; 14(8):e0221188. doi: 10.1371/journal.pone.0221188. PMID: 31412091; PMCID: PMC6693748. 

Geißler K, Bohne S, Siggel R, Sachse S, Kiehntopf M, Bauer M, Straube E, Guntinas-Lichius O. Preoperative serum pattern analysis to predict the outcome of tonsillectomy in adults with chronic tonsillitis. Eur Arch Otorhinolaryngol. 2014 Oct; 271(10):2803-11. doi: 10.1007/s00405-014-3084-5. Epub 2014 May 11. PMID: 24816834 

Grosheva M, Shabli S, Volk GF, Sommer B, Ludwig L, Finkensieper M, Wittekindt C, Klussmann JP, Guntinas-Lichius O, Beutner D. Sensation loss after superficial parotidectomy: A prospective controlled multicenter trial. Head Neck. 2017 Mar; 39(3):520-526. doi: 10.1002/hed.24647. Epub 2017 Jan 9. PMID: 28067982.

Grosheva M, Horstmann L, Volk GF, Holler C, Ludwig L, Weiß V, Finkensieper M, Wittekindt C, Klussmann JP, Guntinas-Lichius O, Beutner D. Frey's syndrome after superficial parotidectomy: role of the sternocleidomastoid muscle flap: a prospective nonrandomized controlled trial. Am J Surg. 2016 Oct;212(4):740-747.e1. doi: 10.1016/j.amjsurg.2016.01.020. Epub 2016 Mar 19. PMID: 27083066. 

Guntinas-Lichius O, Geißler K, Preußler NP, Meißner W. Optimale Schmerztherapie nach Tonsillektomie: ein ungelöstes Problem [Optimal Postoperative Pain Management After Tonsillectomy: An Unsolved Problem]. Laryngorhinootologie. 2016 Jan;95(1):15-23. German. doi: 10.1055/s-0041-107985. Epub 2016 Jan 12. PMID: 26756653. 

Machiels JP, Haddad RI, Fayette J, Licitra LF, Tahara M, Vermorken JB, Clement PM, Gauler T, Cupissol D, Grau JJ, Guigay J, Caponigro F, de Castro G Jr, de Souza Viana L, Keilholz U, Del Campo JM, Cong XJ, Ehrnrooth E, Cohen EE; LUX-H&N 1 investigators. Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial. Lancet Oncol. 2015 May; 16(5):583-94. doi: 10.1016/S1470-2045(15)70124-5. Epub 2015 Apr 16. PMID: 25892145. 

Mueller J, Boeger D, Buentzel J, Esser D, Hoffmann K, Jecker P, Mueller A, Radtke G, Geißler K, Bitter T, Guntinas-Lichius O. Population-based analysis of tonsil surgery and postoperative hemorrhage. Eur Arch Otorhinolaryngol. 2015 Dec; 272(12):3769-77. doi: 10.1007/s00405-014-3431-6. Epub 2014 Dec 11. PMID: 25502742. 

Kaplan EL, et al. (1971) Diagnosis of streptococcal pharyngitis: differentiation of active infection from the carrier state in the symptomatic child. Journal Inf Dis 123:490-501 

Kassenärztliche Vereinigung Nordrhein (2015), Tonsillotomie, http://www.kvno.de/10praxis/50qu alitaet/20leistungen_a-z/tonsillotomie/index.html (15. Juni 2015) 

Klauber J et al. (2016) Versorgungs-Report 2015/2016 „Kinder und Jugendliche“, Stuttgart 2016 

Komaroff AL, et al. (1986) The prediction of streptococcal pharyngitis in adults. J Gen Int Med 1 (1):1-7 

Lock C, Wilson J, Steen N, Eccles M, Mason H, Carrie S, Clarke R, Kubba H, Raine C, Zarod A, Brittain K, Vanoli A, Bond J. North of England and Scotland Study of Tonsillectomy and Adeno-tonsillectomy in Children (NESSTAC): a pragmatic randomised controlled trial with a parallel non-randomised preference study. Health Technol Assess. 2010 Mar; 14(13):1-164, iii-iv. doi: 10.3310/hta14130 

Mueller J, Boeger D, Buentzel J, Esser D, Hoffmann K, Jecker P, Mueller A, Radtke G, Geißler K, Bitter T, Guntinas-Lichius O. Population-based analysis of tonsil surgery and postoperative hemorrhage. Eur Arch Otorhinolaryngol. 2015 Dec; 272(12):3769-77. doi: 10.1007/s00405-014-3431-6. Epub 2014 Dec 11. PMID: 25502742. 

Oertel K, Guntinas-Lichius O, Bitter T. Einseitige Vorwölbung derTonsillenregion [Unilateral swell of the tonsilar region]. Laryngorhinootologie. 2014 Jul; 93(7):467-8. German. doi: 10.1055/s-0033-1361170. Epub 2013 Dec 20. PMID: 24363195. 

Piqueras S, Krafft C, Beleites C, Egodage K, von Eggeling F, Guntinas-Lichius O, Popp J, Tauler R, de Juan A. Combining multiset resolution and segmentation, for hyperspectral image analysis of biological tissues. Anal Chim Acta. 2015 Jun, 30; 881:24-36. doi: 10.1016/j.aca.2015.04.053. Epub 2015 May 2. PMID: 26041517. 

Plontke SK et al. (2016) Multicenter trial for sudden hearing loss therapy - planning and concept. HNO. 2016 Apr; 64(4):227-36 

Rubie I et al. (2015) The NAtional randomised controlled Trial of Tonsillectomy IN Adults (NATTINA): a clinical and cost-effectiveness study: study protocol for a randomised control trial. Trials: 6; 16:263 

Schroeder BM (2003) Diagnosis and management of group A streptococcal pharyngitis. Am Fam Phys 67:880, 883-884 

Shvartzman P (1994) Are antibiotics appropriate for sore throats? Careful prescribing is beneficial. BMJ 309:1011-1012.

Skevas T et al. (2012) Development and validation of the Tonsillectomy Outcome Inventory 14. HNO: 60(9):801-6 

Steinbichler T et al. (2014) Evaluation of a German version of the tonsil and adenoid health status instrument. J Otolaryngol Head Neck Surg: 31; 43:41.  

Ware JE et al (1996) A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care: 34:220–33  

Weigel C, Geißler K, Markwart R, Schubert K, Rubio I, Guntinas-Lichius O, Requardt RP. Isolation of viable and functional T-cells from human palatine tonsils. J Immunol Methods. 2015 Dec; 427:66-72. doi: 10.1016/j.jim.2015.10.002. Epub 2015 Oct 20. PMID: 26472683. 

Windfuhr JP, et al. (2015) Tonsillotomy: facts and fiction. Eur Arch Otorhinolaryngol 272:949-69 

Windfuhr JP, et al. (2016) Clinical practice guideline: tonsillitis II. Surgical management. Eur Arch Otorhinolaryngol 273 (4):989-1009 

Witsell DL et al. (2009) Quality of life after tonsillectomy in adults with recurrent or chronic tonsillitis. Otolaryngol Head Neck Surg: 138(1 Suppl):S1-8. 

Zielske J, Bohne S, Axer H, Brunkhorst FM, Guntinas-Lichius O. Dysphagie- Management im Akut- und Langzeitverlauf bei kritisch kranken intensivpflichtigen Patienten [Dysphagia management of acute and long-term critically ill intensive care patients]. Med Klin Intensivmed Notfmed. 2014 Oct; 109(7):516-25. German. doi: 10.1007/s00063-013-0217-3. Epub 2013 Feb 22. PMID: 23430119. 

Zielske J, Bohne S, Brunkhorst FM, Axer H, Guntinas-Lichius O. Acute and long-term dysphagia in critically ill patients with severe sepsis: results of a prospective controlled observational study. Eur Arch Otorhinolaryngol. 2014 Nov; 271(11):3085-93. doi: 10.1007/s00405-014-3148-6. Epub 2014 Jun 27. PMID: 24970291.

Deutsches Studienzentrum HNO-Heilkunde, Kopf-Hals-Chirurgie
Universitätsklinikum Jena
Universitätsmedizin Göttingen